Marion E. Cole, MD

Panelists discuss how the Mirasol trial's demonstration of superior response rates (42% vs 15.9%) and overall survival (16.5 months) for the FDA-approved folate receptor alpha-positive ADC represents a revolutionary advancement in platinum-resistant ovarian cancer treatment, offering patients prolonged responses with better tolerability and quality of life compared to standard chemotherapies.

Panelists discuss how overcoming barriers to molecular testing in ovarian cancer requires addressing logistical challenges like tissue availability and external pathology coordination, managing financial constraints through institutional support and low-cost options, and enhancing patient communication by clearly explaining how testing creates a personalized treatment roadmap that empowers patients to pursue tailored therapies based on their tumor's genetic and molecular profile.

Panelists discuss how molecular testing strategies prioritize BRCA and HRD status at diagnosis while incorporating folate receptor alpha and other biomarkers in the recurrent setting to guide treatment decisions and clinical trial eligibility.

Panelists discuss how treatment approaches differ between platinum-sensitive and platinum-resistant ovarian cancer patients, emphasizing the use of platinum doublets and maintenance therapies in sensitive cases versus the limited options historically available for resistant cases.